> For the complete documentation index, see [llms.txt](https://help.tso500software.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.tso500software.illumina.com/reference/resources-references.md).

# Revision History

Please visit [TruSight Oncology 500 Documentation](https://support.illumina.com/sequencing/sequencing_kits/trusight-oncology-500/documentation.html) support page for release notes and additional information.

## Revision History

<table><thead><tr><th width="175">Revision</th><th width="224">Date</th><th>Details</th></tr></thead><tbody><tr><td>09</td><td>October 6, 2026</td><td>Documentation for supplemental workflows including MTAP Spike-in using DRAGEN Enrichment</td></tr><tr><td>08</td><td>August 5, 2026</td><td>Support for NovaSeq X 5B</td></tr><tr><td>07</td><td>May 26, 2026</td><td>Update to Performance Testing section and to support release of DRAGEN TSO 500 ctDNA v2.6.4</td></tr><tr><td>06</td><td>December 19, 2025</td><td>Update to remove reporting limit for absolute copy number for DRAGEN TSO 500 v2.5 and v2.6</td></tr><tr><td>05</td><td>November 13, 2025</td><td>Updates for release of DRAGEN TSO 500 ctDNA v2.6.3 with support for NextSeq 2000 (P4), NovaSeq X 25B, NovaSeq 6000 S1</td></tr><tr><td>04</td><td>July 30, 2025</td><td>Updates for release of DRAGEN TSO 500 v2.6.2 with TSO 500 v2 assay support</td></tr><tr><td>03</td><td>May 15, 2025</td><td>F2 support for pipelines on BioInsight Platform Core</td></tr><tr><td>02</td><td>January 2025</td><td>Updates for multi-version support (local releases): DRAGEN TSO 500 v2.5.4, DRAGEN TSO 500 v2.6.1, DRAGEN TSO 500 ctDNA v2.6.2</td></tr><tr><td>01</td><td>December 16, 2024</td><td>Initial release of DRAGEN TSO 500 ctDNA v2.6 guide &#x26; DRAGEN TSO 500 v2.5</td></tr><tr><td>00</td><td>October 25, 2024</td><td>Initial release of DRAGEN TSO 500 v2.6.0 Software User Guide</td></tr></tbody></table>


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