Analysis Methods
The software processes sequencing data to perform quality control, detect variants, determine tumor mutational burden (TMB), microsatellite instability (MSI) status, and genomic instability score (GIS), and report results. The following sections describe the analysis methods used in DRAGEN TruSight Oncology 500 Analysis Software.
DRAGEN TruSight Oncology 500 Analysis Software uses the following workflows to analyze sequencing data.
FASTQ Generation
DNA Analysis
DNA Alignment and Error Correction
Small Variant Calling and Filtering
Copy Number Variant (CNV) Calling
BRCA Large Rearrangements
Annotation
Tumor Mutational Burden (TMB) Scoring
Microsatellite Instability (MSI) Status
Genomic Instability Score (GIS)
Tumor purity (beta)
Ploidy (beta)
Absolute Copy Number (beta)
Gene-level Losss of Heterozygosity (LOH) (beta)
Contamination Detection
RNA Analysis
Downsampling
Read Trimming
Alignment
Fusion Calling and Filtering
Splice Variant Calling
Fusion Merging
Annotation
Quality Control
Run QC
DNA Sample QC
RNA Sample QC
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