Block List

The block list represents high noise regions in the panel where false positive variant calls are likely produced. As a result, all positions in the gVCF are marked as Filter=excluded_regions to indicate variant call results are not reliable in such regions.

The block list includes the following genes:

• HLA A

• HLA B

• HLA C

• KMT2B

• KMT2C

• KMT2D

• chrY

• Any position with VAF 1% occurrence in six or more of the 60 baseline samples.