DRAGEN TSO 500 and TSO 500 ctDNA Analysis Software
  • DRAGEN TSO 500 and TSO 500 ctDNA Analysis Software
  • DRAGEN TSO 500 Guides
    • DRAGEN TSO 500 v2.6
      • Introduction to DRAGEN TSO 500 Analysis Software v2.6.x
      • Getting Started
        • Installation of 2.6.0 on Standalone DRAGEN Server
        • Installation of 2.6.1 on Standalone DRAGEN Server
        • Getting Started on Illumina Connected Analytics
        • Installation of NovaSeq 6000Dx TSO 500 Analysis Application
      • Run Planning
        • Sample Sheet Introduction
        • Sample Sheet Requirements
        • Sample Sheet Creation in BaseSpace Run Planning tool
        • NovaSeq 6000Dx Run Set Up
        • Sample Sheet Templates
      • Launching Analysis
        • Analysis Launch on Standalone DRAGEN Server
          • Command-Line Options
          • Run on Multiple DRAGEN Servers
        • Analysis Launch on ICA
          • Auto-Launch of DRAGEN TSO 500 Analysis on ICA
          • Manual Launch of DRAGEN TSO 500 Analysis on ICA
      • Analysis Output
        • DNA Output
        • RNA Output
        • Combined Variant Output
        • Metrics Output
          • DNA Expanded Metrics
          • RNA Expanded Metrics
          • HRD Metrics Report
        • Coverage Reports
        • Block List
      • Analysis Methods
        • FastQ Generation
        • DNA Analysis Methods
        • RNA Analysis Methods
        • Quality Control
        • Performance Testing
      • Troubleshooting
    • DRAGEN TSO 500 v2.5
      • Introduction to DRAGEN TSO 500 Analysis Software v2.5.x
      • Getting Started
        • Installation of 2.5.3 on Standalone DRAGEN Server
        • Installation of v2.5.4 on Standalone DRAGEN Server
        • Getting Started on Illumina Connected Analytics
      • Run Planning
        • Sample Sheet Introduction
        • Sample Sheet Requirements
        • Sample Sheet Creation in BaseSpace Run Planning tool
        • Sample Sheet Templates
      • Launching Analysis
        • Analysis Launch on Standalone DRAGEN Server
          • Command-Line Options
          • Run on Multiple DRAGEN Servers
        • Analysis Launch on ICA
          • Auto-Launch of DRAGEN TSO 500 Analysis on ICA
          • Manual Launch of DRAGEN TSO 500 Analysis on ICA
      • Analysis Output
        • DNA Output
        • RNA Output
        • Combined Variant Output
        • Metrics Output
          • DNA Expanded Metrics
          • RNA Expanded Metrics
          • HRD Metrics Report
          • Block List
        • Analysis Methods
          • FASTQ Generation
          • DNA Analysis Methods
          • RNA Analysis Methods
          • Quality Control
          • Performance Testing
      • Troubleshooting
  • DRAGEN TSO 500 ctDNA Guides
    • DRAGEN TSO 500 ctDNA v2.6
      • Introduction to DRAGEN TSO 500 ctDNA Analysis Software v2.6
      • Getting Started
        • Installation of TSO 500 ctDNA v2.6.0 on Standalone DRAGEN Server
        • Installation of TSO 500 ctDNA v2.6.2 on Standalone DRAGEN Server
        • Getting Started on Illumina Connected Analytics
        • Installation of NovaSeq 6000Dx TSO 500 ctDNA Analysis Application
      • Run Planning
        • Sample Sheet Introduction
        • Sample Sheet Requirements
        • Sample Sheet Creation in BaseSpace Run Planning tool
        • NovaSeq 6000Dx Run Set Up
        • Sample Sheet Templates
      • Launching Analysis
        • Analysis Launch on Standalone DRAGEN Server
          • Command-Line Options
        • Analysis Launch on ICA
          • Auto-Launch of DRAGEN TSO 500 ctDNA Analysis on ICA
          • Manual Launch of DRAGEN TSO 500 ctDNA Analysis on ICA
      • Analysis Output
        • DNA Output
        • Combined Variant Output
        • Metrics Output
          • DNA Expanded Metrics
        • Coverage Reports
        • Block List
      • Analysis Methods
        • FastQ Generation
        • DNA Analysis Methods
        • Quality Control
      • Troubleshooting
  • Reference
    • Revision History
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  • Prerequisites
  • Installation Instructions
  • External Storage Configuration

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  1. DRAGEN TSO 500 ctDNA Guides
  2. DRAGEN TSO 500 ctDNA v2.6
  3. Getting Started

Installation of NovaSeq 6000Dx TSO 500 ctDNA Analysis Application

Instructions to install DRAGEN TSO 500 ctDNA Analysis Application on NovaSeq 6000Dx (RUO mode)

Prerequisites

The following requirements must be met to install and run DRAGEN TruSight Oncology 500 ctDNA Analysis Application on NovaSeq 6000Dx:

  • A NovaSeq 6000Dx sequencing instrument with Illumina Run Manager v1.6.2 or later installed and paired with DRAGEN Server v4.

  • Administrator privileges on Illumina Run Manager.

Installation Instructions

Perform the following steps to download and install the DRAGEN TruSight Oncology 500 ctDNA Analysis Application on NovaSeq 6000Dx installation package:

  1. Contact Illumina Customer Care for the link to the installation package. The link expires after 7 days.

  2. Download the installation package with the link provided in the email from Illumina Customer Care. The installation package contains the following files:

    1. DRAGEN IRES file: drageninstaller_<DRAGEN_VERSION>.el8.x86_64_prod.ires

    2. Illumina Run Manager: TSO500L_v<APP_VERSION>.iapp

  3. Install the DRAGEN version using the IRES file.

    1. Log into Illumina Run Manager as an administrator.

    2. From the Settings menu, select DRAGEN.

    3. Select Add DRAGEN Installer.

    4. Select the DRAGEN IRES file to begin installation.

    5. Check the install versions list to verify that the appropriate DRAGEN version is listed

  4. Install the Illumina Run Manager-compatible application.

    1. Log into Illumina Run Manager as an administrator.

    2. From the left-hand menu, select Applications.

    3. Select the RUO tab, select Install Application, and then select the IAPP file to install the application.

    4. Check the RUO Applications list to verify that the appropriate application version is listed. You can configure application settings such as required users from this list.

External Storage Configuration

Perform the following steps to specify a location to store analysis results:

  1. Log into Illumina Run Manager as an administrator.

  2. From the Settings menu, select External Storage for Analysis Results.

  3. Configure the following parameters:

    1. Server Location: The path of the preferred output file location. A change to the server location may prompt you to enter the domain, user name, and password to the new server location.

      1. In addition to storing the analysis results from any sequencing runs, this location contains the input data created when setting up runs. Make sure that the server location has sufficient storage space for your run.

    2. Encryption—Select Require encryption during file transfer.

  4. Select Save to preserve the changes to the external storage output parameters.

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